Wetenschappelijk veldonderzoek naar maïs als biosensor voor het meten van DNA-schade als gevolg van milieustress
The maize plants have been edited using the CRISPR/Cas9 system resulting in the mutation of either the ATR or ATM gene. There are three events: one event with one additional DNA basepair in the ATR gene, one event with one additional DNA basepair in the ATM gene and one event with a 1272 bp deletion in the ATR gene. The result of these alterations is that these genes are no longer functional. The ATR and ATM genes gene plays a role in the repair of DNA damage and in these plants faults in the DNA are believed to accumulate to a higher degree.
Scientific field evaluation of maize with an impaired DNA-repair mechanism and maize with modified growth characteristics
Maize plants edited using the CRISPR/Cas9 system resulting in a single base pair mutation in either the ALT gene (that plays a role in the repair of DNA damage) or the NGAL2 gene (a transcription factor that has been shown to negatively affect the expression of the PLA1 gene coding for a cytochrome P450 mono-oxygenase enzyme).
