| 
            Only notified under the "contained use" procedure. Dossier submitted on 20/08/2018.           | 
                  
            A Phase I/II study of the safety and efficacy of a single dose of autologous CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells in subjects with severe sickle disease           | 
                  
                  
            Humans           | 
                  
            Modified cells expressing Hemoglobin F (HbF)           | 
              
          
                  | 
            Only notified under the "contained use" procedure. Dossier submitted on 05/07/2005.           | 
                  
            A multicenter, randomized, double-blind, placebo-controlled study evaluating the efficacy of Biobypass (ADGVVEGF121.10NH) delivered by NOGATM-guided/MYOSTARTM catheter in "no option" patients with class II-IV stable angina           | 
                  
                  
            Humans           | 
                  
            human VEGF121           | 
              
          
                  | 
            Only notified under the "contained use" procedure. Dossier submitted on 01/02/2005.           | 
                  
            A Controlled, Randomised, Parallel Group, Multicentre Study of the Efficacy and Safety of Herpes Simplex Virus-Thymidine Kinase Gene Therapy (CereproTM), with Subsequent Ganciclovir, for the Treatment of Patients with Operable High-Grade Glioma            | 
                  
                  
            Humans           | 
                  
            Thymidine Kinase (HSV-TK1)           |